After a lot of testing I discovered that it wasn't the Thrustmasters.
When more then 3 or 4 (depending on which devices) were connected the problems started...
With just 3 USB devices everything worked fine.
I got a special test BIOS from ASUS but this one didn't solve the problems. In fact they were worse.
After entering the BIOS and then exiting, also my keyboard was gone in BIBM... And sometimes if there was a working mouse (with less USB devices connected), the mouse would left click by itself.
After filling forms with used hardware they said they could not reproduce the problem...
After giving serial numbers of the hardware and used USB ports they were silent for some weeks.
Now again they say they can't reproduce the problem and there was a new BIOS to download.
With this new BIOS there is a working mousecursor sometimes, but when placing it over a button it executes by itself (it leftclicks by itself). If I click the left mousebutton and keep it there I can move the cursor everywhere without a problem but if I lift the left button the cursor is autoexecuting again...
I now have an non existing partition defined at the place where the cursor is in the boot menu when I boot, because otherwise the partition underneath the cursor would boot by default when accidentally moving the mouse...
And now I'm waiting for it to autodelete partitions and me losing important data...
(maybe a 'no mouse' option in settings would be useful now; TeraByte Unlimited?)
I always loved ASUS for there hardware. Not there software. It has always been buggy from start to finish... DON'T ever use their software..!!!
And after a year or two they don't update their lacking BIOSes. My 7 year old MOBO in my previous system still uses the latest BIOS... It's a BETA... They never ended with a final version... its pathetic. They are amateurs...
The Bootcontroller supports 2TB. The datacontroller doesn't... Well it does, but that one needs a BIOS update... And ASUS won't do it...

(as far is I remember Intel did in there MoBo's)
Although I do have better Legacy Mouse support with BING in that older ASUS MOBO compaired to my current P8P76 DELUXE.
They'd better call it P8P67 NIGHTMARE.
I think it's time to never ever buy any ASUS product ever again. They just suck your wallets empty and after that they are gone. Leaving you with beautiful hardware that only works half...
There was an Eee Pad Transformer with Windows 8 on my list, but that one is of my list now.
Is GigaByte better with there BIOS (updates), or will I have to go back to Intel MoBo's..?